Thursday, January 31, 2013

Discovery of sexual mating in Candida albicans could provide insights into infections

Jan. 30, 2013 ? Like many fungi and one-celled organisms, Candida albicans, a normally harmless microbe that can turn deadly, has long been thought to reproduce without sexual mating. But a new study by Professor Judith Berman and colleagues at the University of Minnesota and Tel Aviv University shows that C. albicans is capable of sexual reproduction.

The finding, published online by Nature January 30, represents an important breakthrough in understanding how this pathogen has been shaped by evolution, which could suggest strategies for preventing and treating the often serious infections that it causes.

The most common fungus that infects humans, C. albicans is part of the large community of microorganisms that live for the most part harmlessly within the human gut. But unlike many of its neighbors, this one-celled yeast can also cause disease, ranging from thrush (an oral infection) and vaginal yeast infections to systemic blood infections that cause organ failure and death and usually occur in people with immune defects related to HIV/AIDS, organ transplantation or chemotherapy. C. albicans is responsible for400,000 deaths annually.

Most single-celled organisms reproduce by dividing, but others reproduce asexually, parasexually or via sexual mating. Scientists have long believed that C. Albicans reproduce without mating.

Organisms that produce asexually or parasexually are diploid, which means they have two sets of chromosomes and thus can reproduce without a mate. Organisms that reproduce sexually are haploid, which means they have one set of chromosomes and need a mate to provide a second set. C. Albicans was believed to be diploid, but this study shows that the yeast is sometimes haploid, and that these haploids are capable of sexual reproduction.

Sexual reproduction fuels the evolution of higher organisms because it combines DNA from two parents to create one organism. The haploid isolates discovered in Professor Berman's lab arise only rarely within a population, and have been detected following propagation in the lab or in a mammalian host. These haploids can mate with other haploids to generate diploid strains with new combinations of DNA, which may provide the diversity required for fungus to evolve.

The haploid C. albicans isolates also pave the way for genetic studies of the pathogen, such as the construction of "libraries" of recessive mutant strains. In addition, the ability to perform genetic crosses between haploids will help produce modified diploid strains that should help scientists better understand interactions between the fungus and its host and how it transforms from a harmless microbe into a deadly pathogen.

Berman holds appointments and has laboratories at the University of Minnesota's College of Biological Sciences and Tel Aviv University.

The work was done in collaboration with researchers at Bowdoin College (Maine), Brown University (Rhode Island), A*STAR (Singapore) and at the Taipei Medical University (Taiwan) and was funded, in part, by the National Institutes of Health.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of Minnesota.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Meleah A. Hickman, Guisheng Zeng, Anja Forche, Matthew P. Hirakawa, Darren Abbey, Benjamin D. Harrison, Yan-Ming Wang, Ching-hua Su, Richard J. Bennett, Yue Wang, Judith Berman. The ?obligate diploid? Candida albicans forms mating-competent haploids. Nature, 2013; DOI: 10.1038/nature11865

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/1FYaYSrBel8/130130143632.htm

wilt chamberlain joe arpaio cat in the hat green eggs and ham wiz khalifa and amber rose oh the places you ll go blunt amendment

Ipad 2 New Features

Ipad 2 New Features images

Oracle Virtual Desktop Client For iPad
New Features in Version 1.0 for iPad This release introduces support for running Oracle Virtual Desktop Client on an iPad tablet computer. • Oracle Virtual Desktop Infrastructure version 3.2.2 or later New Features and Supported Platforms 2. Chapter 2. ? Fetch This Document

Ipad 2 New Features

iPad 2
Getting around- How to use iPad 2 iCloud features: http://www.apple.com/icloud/features/ • Top iPad Tips and Tricks ? http://www.tcgeeks.com/30-essential-ipad-tips/ • New users guide, TC Geeks ? http://www.tcgeeks.com/how-to-use-ipad-2/ ? Fetch Document

Apple Ipod 2 Guide Tour Ipod HD ? YouTube
2:09 ? New iPad 2 Review ( New Features, Cool apps) March 5th by Wissile Sogoyou 5,546 views; 1:21 iPad 2 Apps Overview by MegaIphoneReviews 14,987 views; 2:11 Apple iPad 2011 2nd Generation Features [HD] by 1991shahan 17,670 views; ? View Video

Ipad 2 New Features pictures

Talk:IPad 2 ? Wikipedia, The Free Encyclopedia
Ipad 2 release date: released in South Africa on the 29.04.2011 (source http://www.apple.com/za/ipad/) and no mention of new OS?s and their features is made in the article. Also, the part about FaceTime is missing several new devices. 24.247.142.120 20:27, 27 November 2012 (UTC) ? Read Article

pictures of Ipad 2 New Features

For iPad
HC -SKIPPER for iPad USER’S GUIDE Page 2 / 10 II. Introduction HC-SKIPPER for iPad (HCS i) is the simple, economic and effective solution to drive one or more Home-Theatre rooms New features • Management of serial ports of Global Caché?s devices ? Return Doc

photos of Ipad 2 New Features

The new iPad
Case features very slim yet sturdy protection for the new iPad. The iPad is Compatible with The new iPad and iPad 2 Compatible with Apple Smart Cover, SPIGEN Skin Guards, and Incredible Shields Available in 3 Colors PRODUCTS SKU Black SGP0885099 $47. ? Retrieve Here

images of Ipad 2 New Features

Apple iPad
Apple iPad Key Features Overview Prepared by: TigerSpike Innovation Lab Date: February 2010 . 2 18 Buckingham Gate, London, SW1E 6LB Phone: +44 (0)20 7802 8005 The iPad gives developers a new ‘pop-over’ screen to utilise in their applications. ? Access Content

pictures of Ipad 2 New Features

iPad 2 ? Wikipedia Bahasa Melayu, Ensiklopedia Bebas
iPad 2 adalah peranti generasi kedua dalam keluarga iPad , sebuah komputer tablet , direka, dibangunkan dan dipasarkan oleh Apple . iPad 2 mempunyai bateri polimer litium yang tahan sehingga 10 jam penggunaan penggunaan, pemproses dual-core Apple A5 dan kamera depan VGA dan kamera belakang 720p ? Read Article

Ipad 2 New Features

EBay For IPhone And iPad Fact Sheet
New Features: Shopping • iPhone 2.7 and iPad 2.2 feature new advanced search capabilities with auto-complete • The apps also include an improved checkout experience – it’s faster, eBay for iPad 2.2 and iPhone 2.7_January 2013 Author: ? Fetch Content

Ipad 2 New Features images

ILuv New iPad Accessories
The new iPad into a powerful portable business device. Festival (iCC2012)-The Festival sleeve features a fun and colorful iLuv-exclusive pattern. The plush interior luxuriously envelopes the new iPad and protects the screen from scratches. ? Fetch Content

pictures of Ipad 2 New Features

The new iPad
–Has all main features (UI, software, hardware) • Windows 8 Pro –Succeeds W7 Pro and Ultimate editions –Targeted for business and power users –Adds domain support, encryption other advanced features The new iPad Author: ? Get Document

';loveClawOptions.API='wp2.22';loveClawOptions.ButtonLabels=['I love it','I hate it','Interesting','Shocking','I don\'t care'];

Source: http://ipad-2-mobile.com/ipad-2-new-features.html?utm_source=rss&utm_medium=rss&utm_campaign=ipad-2-new-features

lisa lampanelli lisa lampanelli bronx zoo memphis grizzlies celebrity apprentice grizzlies bronx zoo crash

Anti-Lynas group enters politics to bring down BN in Pahang

http://www.themalaysianinsider.com/images/uploads/2013/january2013/m_wongtack301.jpg

(TMI) -?Environmental group Himpunan Hijau today said it will campaign against the Barisan Nasional (BN) coalition in Pahang in its bid to stop Lynas from operating its controversial rare-earth plant in the state.

?

?Himpunan Hijau from today onwards is entering politics,? the group?s chairman Wong Tack(picture)?told a press conference today, saying that Himpunan Hijau wants to change the state government.

At the launch of the group?s ?Pahang Green Corridor? campaign today, Himpunan Hijau said it will campaign for federal opposition Pakatan Rakyat (PR) and will focus more on six out of eight parliamentary constituencies and 14 out of 23 state constituencies in that zone.

?

?Our job now...is to make sure our team will be down to the?kampung?(village) and visit every single family and reach every quarter of society,? Wong Tack said, adding that the group will set up committees called Angkatan Mat Kilau to giveceramah?(talks) and spread information among those in the rural areas.

When asked what is the assurance that PR will stop the Lynas project if it wrests control of Pahang, Wong said the group has given up hope on the ruling BN coalition.

?We have verbal assurance from the Pakatan Rakyat that if they are in power, they will close down Lynas...so we take this promise seriously,? Wong said.

Read more at:?http://www.themalaysianinsider.com/malaysia/article/anti-lynas-group-enters-politics-to-bring-down-bn-in-pahang/?




busy

Source: http://malaysia-today.net/mtcolumns/newscommentaries/54186-anti-lynas-group-enters-politics-to-bring-down-bn-in-pahang

aspergers Richard Engel Daniel Inouye steelers scarlett johansson tim tebow survivor

Sony Music Unlimited now offers 320 kbps AAC high-quality streaming

Sony Music Unlimited

Sony's Music Unlimited streaming service is being updated today to offer high-quality 320 kbps AAC?music on all platforms, including Android. The service, which offers unlimited (go figure) music streaming for the monthly price of $9.99, is hoping to persuade users to try it over competing services like Spotify and Rdio. 320 kbps AAC is generally regarded as a high enough quality streaming that general users won't notice the difference between it and locally stored files, but also keeps data usage from streaming reasonably low.

You can download the Music Unlimited app from the Play Store link above, and there is currently a 14 day free trial available when you sign up. The higher quality audio may be enough to have more users trying this service going forward.

320kbps AAC Streaming Playback Now Available for PlayStation 3, Android Smartphones and Tablets, and PCs

FOSTER CITY, California, Jan. 29, 2013 /PRNewswire/ -- Sony Network Entertainment International today announced that the company's Music Unlimited service now offers users the ability to listen to high quality audio through the service's PC (Windows? and Mac OS?), Sony Xperia? and other Android? smartphones and tablets, Sony Android Walkman?, and PlayStation?3 (PS3?) computer entertainment system applications.? By turning on the high quality streaming option in Music Unlimited's settings menu, songs will playback in pristine 320 kbps AAC high fidelity audio.
Sony Entertainment Network's Music Unlimited service is a cloud-based digital music service that hosts a global catalog of over 18 million licensed songs(1) and is available on a wide range of Sony and non-Sony connected devices including any personal computer (including Windows and Mac OS), iOS devices including iPhone? and iPod touch?, Android devices including Sony Xperia smartphones and tablets, as well as the PS3, PlayStation?Vita, and connected Sony BRAVIA HDTVs as well as various Sony home audio and video devices.

The new feature, which is now live on the PS3, Android smartphone and tablet, Android Walkman, and web apps, will be added to other devices compatible with the Music Unlimited service later this year.

Additional information about Sony Entertainment Network can be found by visiting: blog.sonyentertainmentnetwork.com, www.facebook.com/sonyentertainment, and www.twitter.com/sonyentnet.?

(1) Number of tracks available from this catalog varies by country and may be less.

Source: http://feedproxy.google.com/~r/androidcentral/~3/J0gqJ54sXxY/story01.htm

cirque du freak paul pierce pope joan pope joan strikeforce tate vs rousey strawberry festival knicks

Wednesday, January 30, 2013

NBA: LaMarcus Aldridge's buzzer-beater caps Portland Trail Blazers' wild comeback

LaMarcus Aldridge's buzzer-beating shot had barely left his hands when teammate Nicolas Batum raised his arms in victory.

Aldridge's turnaround jumper fell as time ran out and the Portland Trail Blazers came back from a 21-point third-quarter deficit to beat the visiting Dallas Mavericks 106-104 on Tuesday night.

"I knew," Batum said. "I knew he was going to make it."

Aldridge finished with 29 points and 13 rebounds for Portland, which trailed 101-94 with 2:18 left. Aldridge also had a 3 -- the first one he's made this season -- to tie it at 104 with 4.9 seconds left. O.J. Mayo was called for charging with 1.5 seconds to go, and Aldridge hit his jumper after the inbound from Wesley Matthews with 0.2 seconds left for the victory.

"(Batum) has his hand up. He said he had a lot of faith in me," said Aldridge, recently named an All-Star reserve for the second straight year. "I had to watch it go in."

Dirk Nowitzki, who scored 26 points in the loss, said, "We cannot let Aldridge get set on the block 10 feet from the basket and let him turn around and shoot a wide-open shot. We make those mistakes, especially on the road, and you are going to get bit.

"This type of loss is about as tough as it gets in the league."

The Blazers' J.J. Hickson had a season-high 26 points and 15 rebounds for his 25th double-double.

The Mavericks were without center Chris Kaman, who sustained a concussion in a collision during practice

Monday, according to coach Rick Carlisle. There was no timetable for Kaman's return.

Lakers 111, Hornets 106: Dwight Howard scored 24 points, Kobe Bryant had 14 points and 11 assists in another pass-first performance, and Los Angeles hung on at home for its first three-game winning streak in five weeks.

However, the Lakers' 18-point lead with 5? minutes to play dwindled to 102-101 with 2 minutes left before Earl Clark and Steve Nash hit big shots to clinch the victory.

Bucks 117, Pistons 90: Brandon Jennings scored 20 of his 30 points in the third quarter, leading visiting Milwaukee.

Rookie Andre Drummond had 18 points and 18 rebounds for Detroit, becoming just the second teenager to have an 18-18 game since 1985-86, joining Dwight Howard.

Timberwolves: Coach Rick Adelman revealed that he was away from the team for three weeks because his wife, Mary Kay, has been suffering seizures.

Adelman returned to the Timberwolves after his hiatus on Monday and declined to talk specifically about what was bothering his wife.

Adelman said Tuesday he was urged by his wife to be more open about the situation. He plans to coach on Wednesday night against the Clippers.

Greg Oden: A person with knowledge of Cleveland's interest said the Cavaliers are exploring the possibility of signing Greg Oden, the former No. 1 overall pick whose NBA career has been sabotaged by a series of knee injuries.

Oden said Tuesday he will not play this season but eyes a comeback for 2013-14.

Players union: Executive director Billy Hunter has fired his daughter and daughter-in-law from the NBA players' association, less than two weeks after a review criticized his hiring practices.

Source: http://www.mercurynews.com/other-sports/ci_22478465/nba-lamarcus-aldridges-buzzer-beater-caps-portland-trail?source=rss

hoodie hoosiers temperance world bank kim kardashian flour bomb hunger games box office xavier

Tuesday, January 29, 2013

Staggering Stats: Cats Kill Billions of Animals a Year

Cats kill billions of birds every year and even more tiny rodents and other mammals in the United States, a new study finds.

According to the research, published today (Jan. 29) in the journal Nature Communications, cats kill between 1.4 billion and 3.7 billion birds and between 6.9 billion and 20.7 billion small mammals, such as meadow voles and chipmunks.

Though it's hard to know exactly how many birds live in the United States, the staggering number of bird deaths may account for as much as 15 percent of the total bird population, said study co-author Pete Marra, an animal ecologist with the Smithsonian Conservation Biology Institute.

Staggering toll

Marra and his colleagues are looking at human-related causes for bird and wildlife deaths in the country, from windmills and glass windows to pesticides.

But first, Marra and his team looked at the impact of the feline population, one of the biggest putative causes of bird demise in the country. ? ? ??

While past studies had used critter cams or owner reports to estimate the number of birds killed by cats, those studies were usually small and not applicable to the entire country, Marra told LiveScience.

For this broader analysis, the team first looked at all prior studies on bird deaths and estimated that around 84 million owned-cats live in the country, many of which are allowed outdoors. [In Photos: America's Favorite Pets]

"A lot of these cats may go outside and go to 10 different houses, but they go back to their house and cuddle up on Mr. Smith's lap at night," Marra said.

Based on an analysis of past studies, the researchers estimated that each of those felines killed between four and 18 birds a year, and between eight and 21 small mammals per year.

But the major scourges for wildlife were not those free-ranging, owned-cats, but instead feral and un-owned cats that survive on the streets. Each of those kitties ? and the team estimates between 30 million and 80 million of them live in the United States ? kills between 23 and 46 birds a year, and between 129 and 338 small mammals, Marra said.

And, it seems, the small rodents taken by felines aren't Norway rats or apartment vermin, but native rodent species such as meadow voles and chipmunks, he added.

No easy answers

One obvious step to reduce the mass wildlife death is to keep kitties indoors, Marra said.

Perhaps seeing their furry friends bring in a meadow vole or a cardinal will spur cat owners to say, "Listen, Tabby, we're going to have a heart-to-heart talk about how much time you spend outside," he said.

Wild cats pose tougher questions, because capture and sterilization approaches have varying levels of success depending on the community, said Bruce Kornreich, a veterinarian at Cornell University's Feline Health Center, who was not involved in the study.

While keeping owned-cats indoors is the best way to benefit both kitties and wildlife, a complete cat ban, like the one recently proposed in New Zealand, is probably not the answer, he said.

For one, it's not clear how completely removing cats from outdoors would affect the ecosystem.

"It may be in some cases that cats may also be keeping other species that may negatively impact bird and other small mammal populations in check," Kornreich told LiveScience.

Follow LiveScience on Twitter @livescience. We're also on Facebook?& Google+.?

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://news.yahoo.com/staggering-stats-cats-kill-billions-animals-162839117.html

school shooting in ohio shooting at chardon high school sasha baron cohen stacy keibler stacy keibler all star game oscar red carpet

New look at cell membrane reveals surprising organization

Jan. 28, 2013 ? Sight would dramatically alter a blind man's understanding of an elephant, according to the old story. Now, a look directly at a cell surface is changing our understanding of cell membrane organization.?

Using a completely new approach to imaging cell membranes, a study by researchers from the University of Illinois, Lawrence Livermore National Laboratory and the National Institutes of Health revealed some surprising relationships among molecules within cell membranes.

Led by Mary Kraft, a U. of I. professor of chemical and biomolecular engineering, the team published its findings in the Proceedings of the National Academy of Sciences.

Cells are enveloped in semi-permeable membranes that act as a barrier between the inside and outside of the cell. The membrane is mainly composed of a class of molecules called lipids, studded with proteins that help regulate how the cell responds to its environment.

"Lipids have multiple functions serving as both membrane structure and signaling molecules, so they regulate other functions inside the cell," Kraft said. "Therefore, understanding how they're organized is important. You need to know where they are to figure out how they're doing these regulatory functions."

One widely held belief among cell biologists is that lipids in the membrane assemble into patches, called domains, that differ in composition. However, research into how lipids are organized in the membrane, and how that organization affects cell function, has been hampered by the lack of direct observation. Although the cell membrane is heavily studied, the imaging techniques used infer the locations of certain molecules based on assumed associations with other molecules.

In the new study, Kraft's team used an advanced, molecule-specific imaging method that allowed the researchers to look at the membrane itself and map a particular type of lipid on mouse cell membranes. The researchers fed lipids labeled with rare stable isotopes to the cells and then imaged the distribution of the isotopes with high-resolution imaging mass spectrometry.

Called sphingolipids (SFING-go-lih-pids), these molecules are thought to associate with cholesterol to form small domains about 200 nanometers across. The direct imaging method revealed that sphingolipids do indeed form domains, but not in the way the researchers expected.

The domains were much bigger than suggested by prior experiments. The 200-nanometer domains clustered together to form much larger, micrometer-sized patches of sphingolipids in the membrane.

"We were amazed when we saw the first images of the patches of sphingolipids across the cell surface," said Peter Weber, who directed the team at Lawrence Livermore National Laboratory. "We weren't sure if our imaging mass spectrometry method would be sensitive enough to detect the labeled lipids, let alone what we would see."

Furthermore, when the researchers looked at cells that were low on cholesterol -- thought to play a key role in lipid aggregation -- they were surprised to find that the lipids still formed domains. On the other hand, disruption to the cell's structural scaffold seemed to dissolve the lipid clusters.

"We found that the presence of domains was somewhat affected by cholesterol but was more affected by the cytoskeleton -- the protein network underneath the membrane," Kraft said. "The central issue is that the data are suggesting that the mechanism that's responsible for these domains is much more complicated than initially expected."

In addition, the new study found that sphingolipids domains were incompletely associated with a marker protein that researchers have long assumed dwelled where sphingolipids congregated. This means that data collected with imaging techniques that target this protein are not as accurate in representing sphingolipid distribution as previously thought.

"Our data are showing that if you want to know where sphingolipids are, look at the lipid, don't infer where it is based on other molecules, and now there's a way to directly image them," said Kraft, who also is affiliated with the department of chemistry at the U. of I.

Next, the researchers plan to use the direct-imaging method in conjunction with other more conventional methods, such as fluorescence, to further determine the organization of different kinds of molecules in the membrane, their interactions and how they affect the cell's function. They plan to begin by targeting cholesterol.

"Cholesterol abundance is important," Kraft said. "You change that, you tremendously change cell function. How is it organized? Is it also in domains? That's related to the question, what's the mechanism responsible for these structures and what are they doing?"

The National Institutes of Health, Lawrence Livermore National Laboratory, the National Science Foundation and the Burroughs Wellcome Fund supported this work. Co-author Joshua Zimmerberg directed research at the Eunice Kennedy Shriver National Institute of Child Health and Human Development, part of the National Institutes of Health.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of Illinois at Urbana-Champaign.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Jessica F. Frisz, Kaiyan Lou, Haley A. Klitzing, William P. Hanafin, Vladimir Lizunov, Robert L. Wilson, Kevin J. Carpenter, Raehyun Kim, Ian D. Hutcheon, Joshua Zimmerberg, Peter K. Weber, and Mary L. Kraft. Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts. PNAS, January 28, 2013 DOI: 10.1073/pnas.1216585110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/dlLKi0xDQOg/130128151924.htm

beach boys tony bennett joe walsh the civil wars duggar miscarriage roman holiday belize

Matters of Taste: The Rest of the Best

Everybody loves a list.

Especially when it involves food. On Thursday I highlighted two of 2012's most scrumptious cocktails. This week I?ll start a run-down of the best food and drink, dynamite destinations, and dining extravaganzas that I encountered in 2012. That means Appetizing Appetizers like the?crispy skinned potato chunks at Jamonera (Philadelphia). Sprinkled with coarse salt and drizzled with a bracing, wood-smoked garlic aioli, they delivered a rapid-fire volley of flavors and textures.?

? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?? 230ce9c04007b9db0caa02f6269c

And Divine Desserts, like the voluptuous Chocolate Bread & Butter Pudding at The Hungry Cat (Santa Barbara) that performs magic with crusty cubes of bread, silken ganache and a bumpy brul?e crust.

? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 6a00e5500fd2388833017616eb93ac970c-320wi

And Pasta dishes that'll make you weep. Case in point: Thomas McNaughton's Flour + Water (San Francisco) Raviolo Doppio of Pork & Pea.

? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?? 6a00e553e7185288330133f08ab1c4970b-800wi

Hungry yet?

Come back and check out the Highlights of 2012.

Source: http://www.maureenclancy.com/2013/01/the-rest-of-the-best.html

Super Bowl Winners barack obama ray lewis dear abby WRAL John Harbaugh jill biden

Scientists discover process that turns normal liver cells to cancer cells

Jan. 28, 2013 ? A team of scientists from the Cancer Science Institute of Singapore (CSI) at the National University of Singapore (NUS) has identified a genetic process in which normal liver cells transform into cancerous ones. The finding provides new understanding into the pathogenesis of human cancers.

The team, which also includes researchers under the direction of Professor Guan Xin-Yuan at The University of Hong Kong, is the first to provide direct evidence that the "editing" of this protein-making sequence promotes the development of cancer.

Normally, deoxyribonucleic acid (DNA), which comprises the genetic code, serves as a template for production of ribonucleic acid (RNA) in precise fashion such that the DNA code and RNA code are identical. Editing is the process in which the RNA is changed after it is made from the DNA, resulting in production of an altered gene product.

This novel study, which was conducted from June 2010 to November 2012, was first published in the online version of Nature Medicine on 6 January 2013.

Focus on RNA

The development of liver cancer is believed to be a multi-step process, in which genetic and epigenetic alterations build up. However, it is much easier technically to detect genetic mutations through DNA sequencing. Epigenetic changes, which by definition do not involve changes in DNA sequence, have not been as well defined because it is much more difficult technically to identify them and demonstrate their role in cancer.

While recent use of next-generation sequencing of DNA and RNA have been suggestive, no apparent causal relationship between the levels of RNA editing, a process of altering RNA sequences, and cancer progression was thought to exist -- until now. As such, RNA editing is a novel epigenetic alteration in cancer.

Recognising the importance of molecular mechanisms that underlay the development of liver cancer, the research team studied the roles that RNA plays in the formation of proteins to carry out functions within the body. The researchers are the first to clearly link the RNA editing event of a protein to be significantly associated with the development of liver cancer.

Professor Daniel Tenen, Director of CSI and Principal Investigator for the study, said, "Up to now, scientists have focused on studying DNA, not RNA. Because RNA can be more easily modified than DNA, it suggests that therapeutic approaches are potentially available."

RNA Editing Process Changes Protein

In the study, the researchers performed genomic analysis of three pairs of tissue samples, each pair comprising a sample of liver cancer tissue and an adjacent non-tumour tissue, from surgical specimens of liver cancer patients.

They found that the RNA editing of a specific gene known as antizyme inhibitor 1 (AZIN1) was much higher in the tumour samples. They discovered that this editing process was catalysed by an enzyme called adenosine deaminase acting on RNA-1 (ADAR1), which changed the product of the AZIN1 protein to a form which promoted the development of cancer.

To verify their findings, the team repeated the tests on paired tissue samples of some 180 liver cancer patients.

The results obtained were consistent with the initial genomic analysis, indicating that the RNA editing of the AZIN1 gene in tumours is significantly associated with the presence of liver cirrhosis, tumor recurrence, and poorer survival rate.

Said Dr Polly Chen, Research Assistant Professor at CSI, and the lead author of the research team, "We believe that there is high possibility that the findings are applicable to other cancers, but further studies are required to ascertain this."

The Next Step

Moving forward, Prof Tenen and Dr Chen will investigate the characteristics of AZIN1 and ADAR1 to further understand their impact on tumour development. They also intend to look at these mechanisms in other cancers. They will also work on ways to correct the RNA editing process so as to block the cells' conversion from normal to malignant.

Both scientists hope that their findings will provide the medical community with a useful biomarker that can be used to detect early disorders leading to liver cancer, and even other forms of cancer, before clinical symptoms become apparent.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by National University of Singapore, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Leilei Chen, Yan Li, Chi Ho Lin, Tim Hon Man Chan, Raymond Kwok Kei Chow, Yangyang Song, Ming Liu, Yun-Fei Yuan, Li Fu, Kar Lok Kong, Lihua Qi, Yan Li, Na Zhang, Amy Hin Yan Tong, Dora Lai-Wan Kwong, Kwan Man, Chung Mau Lo, Si Lok, Daniel G Tenen, Xin-Yuan Guan. Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nature Medicine, 2013; DOI: 10.1038/nm.3043

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/NhGyeFUzQow/130128104424.htm

calvin johnson festivus festivus nfl playoff picture nfl playoff picture Peter Billingsley Larry King

Monday, January 28, 2013

BaFin probes lenders Deutsche Bank over Euribor: paper

FRANKFURT (Reuters) - German regulator BaFin has launched a special probe against four lenders including Deutsche Bank as part of an investigation into possible manipulation of the Europe Interbank Offered Rate (Euribor), the Sueddeutsche Zeitung newspaper reported on Monday.

A special probe is the most severe kind of investigation the regulator can launch against a bank.

The German regulator is also investigating Portigon AG , Sueddeutsche Zeitung said, without citing sources. Portigon is what remains following the breakup of the bank that used to be known as WestLB.

Officials at Deutsche Bank and BaFin were not available for comment. Portigon officials were also not available for comment.

The special probes were launched after BaFin had asked for information from all German banks involved in setting Euribor rates, Sueddeutsche said.

Euribor and its larger counterpart, Libor, or the London Interbank Offered Rate, are Europe's key gauges of how much banks pay to borrow from their peers and are used to set the prices of swathes of financial products, from Spanish home mortgages to more complex derivatives.

Deutsche Bank is already being subjected to a BaFin special probe in connection with Libor.

Deutsche Bank has said it is cooperating with investigations in the United States and Europe in connection with setting rates between 2005 and 2011.

In July, Reuters reported that several banks under investigation for suspected rigging of Euribor intensified cooperation with EU antitrust regulators in the hope of lower fines.

Earlier this month German bank BayernLB said it has withdrawn from the Euribor panel, effective at the start of 2013, citing "strategic reasons".

More than 40 banks still contribute to the Euribor inter-bank lending rate, but the Euribor-EBF group running it warned recently that more could leave following recent bad publicity.

The daily Libor poll asks banks at what rate they think they will be able to borrow money from each other in 10 major currencies and for 15 borrowing periods ranging from overnight loans to 12 months.

As the credit crisis intensified between 2006 and 2008, allegations started mounting that Libor no longer reflected the real cost banks were paying for funds. Authorities have been examining whether traders tried to influence the rate to profit on bets on the direction it would go.

(Reporting By Edward Taylor; Editing by Matt Driskill)

Source: http://news.yahoo.com/bafin-probes-deutsche-bank-over-euribor-well-libor-053007232--sector.html

columbus day Stacy Dash Amber Tamblyn Lilit Avagyan Nashville TV Show VP debate drew brees

Sunday, January 27, 2013

Basking in the shadows? Regulators are watching you

DAVOS, Switzerland (Reuters) - Unconventional lenders that have enjoyed a cozy spot while central bankers were busy trying to make banks stronger should watch out as shadow banking is coming back on to regulators' agenda.

Shadow banking, broadly described as intermediation by non-banks such as hedge funds, private capital and venture funds, has so far escaped traditional banking regulation even though some regulators say it worsened the global financial crisis.

Rebuilding bank capital and the fight to save the euro have taken absolute priority over the past five years.

But Financial Stability Board head Mark Carney told the World Economic Forum in Davos that central bankers will finally be addressing this "forgotten bit of reform" as they try to complete a overhaul of financial regulation over the next two years.

"Shadow banking, over-the-counter derivatives, these are the areas that absolutely amplified the last crisis and will do so again unless we complete our agenda," said Carney, who will leave his current job of Bank of Canada governor to head the Bank of England in July.

The shadow banking sector has been booming since the onset of the global financial crisis in 2007 and stood at $67 trillion worldwide last year according to data from the FSB.

The fact that banks had been forced to hoard capital to build larger buffers against risks has opened up room for new, non-bank players to come into these segment, especially to provide credit to smaller firms.

"Shadow banking is a reality. Investors that had been traditionally providing equity are now providing debt," said Stefano Aversa, co-president of AlixPartners.

"This is not just the traditional loan-to-own space but we also see much loan-to-loan to fill up the gap created by the credit crunch."

NEW PROPOSALS

The FSB is expected to make proposals on how to regulate this dark area of the financial sector before the G20 autumn summit in Russia, where the issue will be debated, regulatory sources told Reuters.

The issue has become controversial also in China, where the $2 trillion sector has come under more closer scrutiny after the default of an unregulated short-term fund distributed through a Shanghai branch of Hua Xia Bank Ltd .

Such high-yield products are known locally as 'wealth management products'.

"You can't say shadow banking is a bad thing simply because a lot of people don't understand it," argued Hony Capital CEO John Zhao, whose firm has $7 billion in assets under management.

"When a country's economy is growing as fast as China's, it's inevitable that different forms of financing will appear. They serve real needs, and serve to fill little areas that the banking system cannot reach."

JP Morgan Chase CEO Jamie Dimon also defended the sector at a panel session in Davos, saying they provided necessary services to the economy.

But AlixPartners' Aversa conceded that there was an issue when it came to transparency.

"We've seen a lot of activity move away from the banks, to the capital markets," Zhu Min, deputy managing director of the International Monetary Fund said.

"Both the banks and the shadow banks should have a proper regulatory framework to govern them."

(Writing by Lisa Jucca, Additional reporting by Kelvin Soh; editing by Jason Neely)

Source: http://news.yahoo.com/basking-shadows-regulators-watching-171430569--sector.html

www.walmart.com Macho Camacho Rise of the Guardians Pumpkin Pie Jack Taylor Apple Pie Recipe black friday

Exclusive: Bank probes find manipulation in Singapore's offshore FX market - source

SINGAPORE (Reuters) - Internal reviews by banks in Singapore have found evidence that traders colluded to manipulate rates in the offshore foreign exchange market, according to a source with knowledge of the inquiries.

The discovery widens a global lending rate scandal into new markets, as fallout from the Libor case puts banks under added scrutiny and spurs both regulators and institutions to reconsider how certain key interest and currency rates are set.

The probes found evidence showing that traders from several banks communicated with each other over electronic messaging about what rates they were going to submit for the local banking association's fixings for non-deliverable foreign exchange forwards (NDFs), aiming to benefit their trading books.

"Traders were talking to traders, saying: 'I need you to help me today, I need to fix low,'" said the bank source, who asked not to be identified due to the confidential nature of the reviews.

NDFs are derivatives that let companies and investors hedge or speculate on emerging market currencies when exchange controls make it difficult for foreigners to participate directly in the spot market.

The contracts are settled in dollars, so there is no exchange of the underlying currency, but they can affect spot exchange rates.

The Monetary Authority of Singapore ordered banks that help set local interbank lending rates and NDF rates to review the fixing process last year as U.S. and British regulators cracked down on manipulation of the London interbank offered rate (Libor), a benchmark used to set interest rates for around $600 trillion worth of securities.

The investigations into Libor led to fines of $1.5 billion for UBS AG and $451 million for Barclays Plc for rate rigging. Regulatory probes stemming from the Libor cases in the United States and Britain have also revealed evidence of attempted manipulation of benchmark interbank lending rates in Tokyo, Hong Kong and Australia.

Banking watchdogs in Britain and elsewhere in Europe have begun trying to reform the way Libor and other interbank rates are set, to try to ensure the numbers can't be manipulated.

The Singapore bank probes show that the focus is now turning to other benchmarks, amid concern that they too were manipulated.

The biggest banks in the Asian NDF markets include UBS, JPMorgan Chase & Co , DBS Group Holdings Ltd and HSBC Holdings Plc .

The source did not make specific comments about possible wrongdoing by individual banks or traders and Reuters has no independent evidence of such wrongdoing.

UBS, JPMorgan, DBS and HSBC declined to comment. Reuters also contacted the other 14 banks involved in setting NDF rates. Twelve said they had no comment while two did not respond to repeated telephone and e-mail requests for comment.

DISCIPLINARY ACTION

Under the NDF rate-setting process, organized by the Association of Banks in Singapore (ABS), banks submit their reading of the spot price for the Indonesian rupiah, Malaysian ringgit and Vietnamese dong every working day at 11:00 a.m. (10 p.m. ET).

A settlement rate for NDF contracts due to expire is then calculated by taking the average of the submissions, excluding the highest and lowest quarters of contributions from the banks.

While the exclusion of the rates at the top and the bottom of the range is meant to ensure that one bank cannot try to improperly skew the rate, the concern is that collusion by traders at multiple banks could influence the result.

There are 18 banks on the panel for the rupiah, 15 for the ringgit and 12 for the dong.

The Monetary Authority of Singapore told banks in the city state last July to review the way they set interbank lending rates, in the wake of the Libor scandal.

As bank officials pored over documents and communications, they came across evidence that raised alarm bells over activities in the NDF markets as well, spurring an extension of the reviews to those markets in September, the source said.

In Singapore, benchmark rates for both interbank lending and certain NDFs are set by panels of banks organized by the ABS. Thomson Reuters, parent company of Reuters News, calculates and distributes the spot reference rates for the rupiah, ringgit and dong NDF markets on behalf of the ABS, as well as other interbank lending and currency rates. "Thomson Reuters supports any measures that create more robust benchmarks for the market and we fully cooperate with regulators, authorities and benchmark sponsors' investigations as required," a Thomson Reuters spokeswoman said.

In December, the Monetary Authority of Singapore issued a statement setting out the banks' obligations under the reviews, although it has not made clear whether it would take action of its own based on the results.

"The banks have to immediately report any irregularities they uncover to MAS, and have to take appropriate disciplinary action against staff involved in such irregularities," the statement said.

"The reviews are ongoing, and it is premature to speculate on the outcome of these reviews at this stage."

The central bank provided no further comment when asked by Reuters about the probes' findings.

The source said most banks had submitted their reviews to the authorities at the end of last year but did not say what disciplinary actions if any were planned for banks or traders who tried to manipulate rates.

The MAS said last year that it was working with the ABS to review the way NDF rates and the city state's benchmark lending rates are set. The association declined to comment for this story.

Banks dealing in over-the-counter products in Singapore such as NDFs follow a code-of-conduct set by the Singapore Foreign Exchange Market Committee, known as The Blue Book.

That includes a requirement that: "dealers and brokers shall not engage in manipulative or deceptive conduct or any form of conduct which would give other users of the market a false or misleading impression as to prevailing market conditions."

MARKET THINS OUT

Trading volumes in the NDF markets are much smaller than for derivatives linked to Libor, although they are hefty enough to effect spot rates for the underlying emerging market currencies.

For the Indonesian rupiah, the biggest market fixed in Singapore, daily turnover is estimated between $700 million and $1.3 billion, according to an HSBC report. Since NDFs are traded over the counter, there is no fixed data on volumes.

Traders say even a small movement in an NDF fixing could have a big impact on a bank's trading book if it had a large number of contracts expiring.

Many of the traders involved were junior and did not appear to think they were doing anything wrong, said the source.

The NDF market in Singapore developed after the Asian financial crisis, when capital fled the region causing several area currencies including the rupiah to slump in value. NDFs gave banks a way around controls that governments subsequently imposed on their currencies to curb those capital flows.

Of the 40 to 50 NDF traders based in Singapore, roughly half had either been put on leave, including those suspended while their activities in the market were under investigation, or left their jobs during the Singapore probes, the source said. It was not clear how many may have been or will be reinstated after the probes' completion.

"A lot of banks are stuck, traders are suspended or have left, so the market is seeing around half its usual volume," the source said.

Flows in Indonesian rupiah and Malaysian ringgit NDFs have been thin since the last quarter of 2012 according to Thomson Reuters IFR Markets, although volumes in ringgit NDFs picked up at the start of this year.

The action by U.S. authorities last month against UBS for its part in the Libor scandal included a criminal charge against the Swiss bank's Japanese subsidiary for yen Libor manipulation.

The charge sheet by the Commodities Futures Trading Commission against the bank also revealed other markets in Asia where problems emerged.

"Through its internal investigation, UBS identified evidence of similar misconduct involving submissions for at least the Hong Kong Interbank Offered Rate ("HIBOR"), the Singapore Interbank Offered Rate ("SIBOR"), the Singapore Swap Offer Rate ("SOR") and the Australian Bank Bill Swap Rate ("BBSW")," a footnote in the charge sheet read.

The Hong Kong Monetary Authority said in December that it was looking into the findings on Hibor.

The Australian Securities and Investments Commission declined to comment on the BBSW.

(Reporting by Rachel Armstrong; Editing by Michael Flaherty and Edmund Klamann)

Source: http://news.yahoo.com/exclusive-bank-probes-manipulation-singapores-offshore-fx-market-210604449--finance.html

nfl news tebow tebow jets romney etch a sketch jeb bush sherry arnold snooty fox

Holocaust archive reunites long lost families

Nearly 70 years after the end of the Second World War, a Holocaust archive in Germany is helping victims and survivors of Nazi atrocities to find clues about the past -- and is still reuniting families. NBC News' Andy Eckardt reports from Bad Arolsen, Germany.

By Andy Eckardt, Producer, NBC News

BAD AROLSEN, Germany -- Wilhelm Thiem may be 72 but he celebrated his first real birthday in November.

Abducted in Poland by Nazi troops aged two, Thiem has spent most of his life on a painful journey seeking to discover his true name and identity.?

Until just a few months ago, the retired entrepreneur had not known his birth date, where he was born, what had happened to his mother or whether he had any other family members.

"I hardly knew anything about my personal history," Thiem said.?"I always felt like an outsider, it was a feeling of not belonging in this world."

Thiem was raised by a foster parent in northern Germany who was appointed by the Nazis to take care of the young child. Thiem called her "Mrs. Huebner" but was later officially adopted and given her maiden name.

At age 12, Thiem learned that Mrs. Huebner was not his real mother. He started asking her about his past, wanting to learn more about his family, but his questions remained unanswered. For decades, his personal history remained a mystery.

Early last year, Thiem came across a newspaper article about the International Tracing Service?(ITS), an organization that maintains a vast archive of files related to more than 17.5 million victims of the Holocaust and Nazi oppression.

"At first the ITS researchers told me that they could not find any documents with my name on them," Thiem recalled. "But then they contacted the Red Cross in Poland and in the end, there were some leads."

'Very emotional moment'
After several months of research, Thiem was informed that he had been born in Lodz, Poland, and that his birth name was Zbigniew Wilhelm Katmierczak.

For the first time in his life, Thiem held a birth certificate in his hands that gave him an identity.

"It was a very emotional moment," Thiem recalled. "Both my wife and I could not hold back tears."

Researchers revealed that his mother was also sent to Germany as a forced laborer but later returned to Poland. She eventually married a Frenchman and relocated to France.

Thiem was also told of a surviving aunt, who still lives in his Polish hometown.

He is now anxiously making plans for a trip to Lodz with his wife for a very special family reunion.

"I am hoping to learn more facts, maybe find other family members," Thiem said. "Maybe I can find traces of my mother and father.?All of this is of huge interest to me, it means so much."

Established by Allies in the final days of the Second World War and originally run by the Red Cross, the ITS helps to uncover the fates of Holocaust victims and others who suffered under the Nazi regime.

The archive in Bad Arolsen is said to be the largest storage facility of documents related to the Holocaust. It includes 30 million documents in 16 miles of shelves housing information about Holocaust survivors, displaced persons, slave laborers and political refugees from former Eastern Bloc countries.

Over the past 50 years, the ITS has answered more than 10 million requests. About 1,000 search requests continue to trickle in to the archive monthly.

"Many people still do not know what has become of their loved ones,"?said Dr. Ingeborg Berggreen-Merkel from Germany's federal commission of culture. "Even decades after the end of the Holocaust and the war, there is this persisting uncertainty, which results from the fact that part of one's own history remains untold."?

Visitors to the archive come into direct contact with the bureaucracy of mass murder.

Its meticulous records include concentration camp files, "deportation cards," patient records and a post-war index of non-German citizens. Its researchers plow through the stacks of yellowing paper, registering and scanning as many of the historic documents as possible. More than 95 percent have now been digitized.

But due to concerns about the victims' privacy, the ITS and the German government kept the files closed to the public for half a century. While search requests have been accepted since the end of the war, the archive was initially not "open source."

Following public pressure from survivor groups, historians and researchers, who called for public access to the archives, the ITS Commission -- consisting of 11 member states -- declared itself in favor of opening up Bad Arolsen in 1998.

Yet, scholars and researchers were only given access to the documents beginning in 2007.

"I think it was criminal that the documents were not opened up earlier," said Holocaust survivor and U.S. judge Thomas Buergenthal. He was able to find?records of his father's ordeal in the concentration camps of Auschwitz, Sachsenhausen and Buchenwald at Bad Arolsen.

"This archive is my father's only memorial, we have no other," Buergenthal added.

But although time has claimed many eyewitnesses, the archive is still helping to reunite survivors of Nazi terror -- such as Thiem and his long lost aunt. She remembers her nephew -- who is now an elderly man -- as a "little child."

"I spent a lifetime wondering who I really am, now I know," Thiem said.

Related:?

A retired teacher's courageous crusade: Tackling neo-Nazi hate

Despite dark past, young Israelis seek new lives in German capital

Warm glow of Berlin's 'beautiful' gas streetlights set to fade

Source: http://worldnews.nbcnews.com/_news/2013/01/26/16641847-holocaust-archive-rescues-lost-identities-reunites-long-lost-families?lite

modesto st louis weather guinea bissau google stock google stock china gdp dont trust the b in apartment 23

Saturday, January 26, 2013

Thousands march for gun control in Washington

WASHINGTON (AP) ? Thousands of people, many holding signs with names of gun violence victims and messages such as "Ban Assault Weapons Now," joined a rally for gun control on Saturday, marching from the Capitol to the Washington Monument.

Leading the crowd were marchers with "We Are Sandy Hook" signs, paying tribute to victims of the December school shooting in Newtown, Conn. Washington Mayor Vincent Gray and other city officials marched alongside them. The crowd stretched for at least two blocks along Constitution Avenue.

Participants held signs reading "Gun Control Now," ''Stop NRA" and "What Would Jesus Pack?" among other messages. Other signs were simple and white, with the names of victims of gun violence.

About 100 residents from Newtown, where a gunman killed 20 first-graders and six teachers, traveled to Washington together, organizers said.

Participant Kara Baekey from nearby Norwalk, Conn., said that when she heard about the Newtown shooting, she immediately thought of her two young children. She said she decided she must take action, and that's why she traveled to Washington for the march.

"I wanted to make sure this never happens at my kids' school or any other school," Baekey said. "It just can't happen again."

Once the crowd arrived at the monument, speakers called for a ban on military-style assault weapons and high-capacity ammunition and for universal background checks on gun sales.

Education Secretary Arne Duncan told the crowd it's not about taking away Second Amendment gun rights, but about gun safety and saving lives. He said he and President Barack Obama would do everything they could to enact gun control policies.

"This is about trying to create a climate in which our children can grow up free of fear," Duncan said. "This march is a starting point; it is not an ending point ... We must act, we must act, we must act."

Del. Eleanor Holmes Norton, D.C.'s non-voting representative in Congress, said the gun lobby can be stopped, and the crowd chanted back, "Yes, we can."

"We are all culpable if we do nothing now," Norton said

James Agenbroad, 78, of Garrett Park, Md., carried a handwritten sign on cardboard that read "Repeal the 2nd Amendment." He called it the only way to stop mass killings because he thinks the Supreme Court will strike down any other restrictions on guns.

"You can repeal it," he said. "We repealed prohibition."

Molly Smith, the artistic director of Washington's Arena Stage, and her partner organized the march. Organizers said that in addition to the 100 people from Newtown, buses of participants traveled from New Jersey, New York and Philadelphia. Others flew in from Seattle, San Francisco and Alaska, they said.

While she's never organized a political march before, Smith said she was compelled to press for a change in the law. The march organizers support Obama's call for gun control measures. They also want lawmakers to require gun safety training for all buyers of firearms.

"With the drum roll, the consistency of the mass murders and the shock of it, it is always something that is moving and devastating to me. And then, it's as if I move on," Smith said. "And in this moment, I can't move on. I can't move on.

"I think it's because it was children, babies," she said. "I was horrified by it."

After the Connecticut shootings, Smith began organizing on Facebook. The group One Million Moms for Gun Control, the Washington National Cathedral and two other churches eventually signed on to co-sponsor the march. Organizers have raised more than $50,000 online to pay for equipment and fees to stage the rally, Smith said.

Lawmakers from the District of Columbia and Maryland rallied the crowd, along with Marian Wright Edelman of the Children's Defense Fund and Colin Goddard, a survivor from the Virginia Tech massacre.

Goddard said he was shot four times at Virginia Tech and is motivated to keep fighting for gun control because what happened to him keeps happening ? and nothing's been done to stop it.

"We are Americans," he said, drawing big cheers. "We have overcome difficulties when we realize we are better than this."

Smith said she supports a comprehensive look at mental health and violence in video games and films. But she said the mass killings at Virginia Tech and Aurora, Colo., and Newtown, Conn., all began with guns.

"The issue is guns. The Second Amendment gives us the right to own guns, but it's not the right to own any gun," she said. "These are assault weapons, made for killing people."

___

March on Washington for Gun Control: http://www.guncontrolmarch.com/

___

Follow Brett Zongker at https://twitter.com/DCArtBeat

Source: http://news.yahoo.com/thousands-march-gun-control-washington-164306917.html

tebow tebow jets romney etch a sketch jeb bush sherry arnold snooty fox el debarge

95% The Central Park Five

All Critics (61) | Top Critics (25) | Fresh (58) | Rotten (3)

Expect your blood pressure to rise during The Central Park Five.

The doc is rife with smart or wrenching or shameful moments. The fresh interviews with the accused, now men, are invaluable.

As grim a portrait of the criminal justice system as can be imagined.

How could this second crime have occurred? The film asks that question but only partly answers it, and in the process it raises an even more troubling one.

"The Central Park Five" is worth seeing, both for the ways it's timeless and for the ways it encapsulates an era.

What's amazing about listening to them speak now, often through tears, is the absence of bitterness.

Like the "Paradise Lost" films, it's a shocking but clear-eyed portrait of injustice.

The Central Park Five is such a moving piece of work, it is difficult to watch at times.

It shows what happens when police and prosecutors abuse their power.

Puts the crime and the times in sharp perspective.

Burns and company conduct a thorough, riveting investigation that does a far better job of assessing the tragedy than the justice system did two decades before. Of course, hindsight is an advantage we all take for granted.

It's a gripping story that comes in a well-crafted package.

A heartbreaking expose' about a rush to judgment which ruined five, innocent young lives.

Exclusive interviews with former heads of Israel's counter terrorism agency reveal insiders' analysis about the country's policies. Fascinating. Frightening.

"The Central Park Five" is a sobering indictment of racism and vigilante justice, yet it is constrained by a PBS-style deference to the very system it critiques.

You can't help but wonder why this film wasn't made 20 years ago, when it could have saved these men some time behind bars.

What keeps the film from being an impossible downer is the guts and spirit and smart words of the Central Park Five, four of whom, now freed, are interviewed at length.

A miscarriage of justice on this scale would have been tragic had it resulted from an honest mistake - but, as this meticulously researched movie makes clear, honesty had little to do with it.

The [documentary] team builds a solid story from the time of the crime through the release from prison those wrongly accused and railroaded into confessing to a crime they did not commit.

No quotes approved yet for The Central Park Five. Logged in users can submit quotes.

Source: http://www.rottentomatoes.com/m/the_central_park_five_2012/

bill cosby us open bill nye Hurricane Isaac 2012 Snooki Baby terrell owens terrell owens

China urges Japan to co-operate in resolving islands dispute

BEIJING (Reuters) - Chinese Communist Party Chief Xi Jinping said on Friday that China's position on a series of islands disputed with Japan is clear and consistent and urged Japan to co-operate in resolving the issue.

Japan should respect the feelings of the Chinese people and "correctly handle" historical problems, Xi told Natsuo Yamaguchi, a visiting lawmaker and head of the junior partner in Japan's ruling coalition.

"The Japanese side ought to face up to history and facts, take practical step and work hard with China to find an effective way to appropriately resolve and manage the issue via dialogue and consultations," Xi said, according to a statement on the Foreign Ministry's website.

The islands are called the Diaoyu in Chinese and the Senkaku by Japan. Relations between the countries are at a low after the Japanese government bought three of the islands last year, sparking widespread, violent anti-Japan protests across China.

(Reporting by Terril Yue Jones and Ben Blanchard; Editing by Nick Macfie)

Source: http://news.yahoo.com/china-urges-japan-co-operate-resolving-islands-dispute-070313989--business.html

carole king crystal renn matilda cab calloway melissa gilbert deadliest catch dwts

Friday, January 25, 2013

AT&T gains customers in 4Q, posts big loss

(AP) ? The launch of the iPhone 5 helped AT&T attract more new customers in the holiday quarter than it has in three years, but it posted a big loss because of an annual adjustment to its pension obligations.

AT&T Inc. on Thursday said added a net 780,000 new customers on contract-based plans from October to December, its best result in three years. It activated 8.6 million iPhones in the quarter ? a record for any company. AT&T was the first company to introduce the iPhone in 2007, and has more iPhone users than any other U.S. carrier.

However, AT&T remained well behind Verizon Wireless, the country's largest cellphone company. It added 2.2 million devices on contract-based plans to its network in the quarter, extending its lead.

Dallas-based AT&T's quarterly loss was $3.86 billion, or 68 cents per share. That compares with a loss of $6.68 billion, or $1.12 per share, a year earlier, also caused by an adjustment to pension and retiree benefit obligations.

Excluding special items, AT&T earned 44 cents per share, 2 cents short of the average analyst estimate as polled by FactSet.

Revenue was $32.6 billion, up a hair from $32.5 billion a year ago. It slightly exceeded analyst estimates of $32.2 billion.

AT&T shares rose 5 cents to $33.80 in extended trading, after the release of the results.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-01-24-US-Earns-ATandT/id-0a1ef28dca1a4327bb1ebf8f9924bd6b

alex jones the bachelor Google Docs Huell Howser Justin Bieber Smoking Weed Katherine Webb Cut for Bieber

Letters to the Editor Friday - Savannah Morning News

Windsor Forest residents, do not conjure up a meeting in response to the recent murders on Savannah?s Southside.

The Windsor Forest Neighborhood Association hosts quarterly meetings, but the majority of residents do not attend.

There is never more than one or two African Americans from the Windsor Forest neighborhood present at these meetings. Most of the folks that do attend these meetings are senior citizens.

What a shame! You do not have to be a homeowner, a college graduate or anyone special to attend these meetings. It costs $20 a year to be a member, but you can participate for free.

More folks need to lead by example. Take a look at some of the yards and houses in Windsor Forest, especially those in the vicinity of the recent Windsor Forest shooting.

It is more than the so-called thugs bringing down our community. It is the lazy homeowners with the derelict properties and yards, the trash on the streets, the cracked and overgrown sidewalks, the overgrown gutters and so forth.

We need to get more involved in our community. Do not blame the thugs for Windsor Forest demise. Look at yourselves and your neighbors first.

ROSE MCGUIRE

Savannah

Wanted: People who have never had cancer

It?s often far too easy to underestimate the importance of cancer research ... until you hear the words ?you have cancer.?

Those three words can make all the difference between simply absorbing news about developments in cancer research and truly appreciating the power of what scientists like those funded by the American Cancer Society do each and every day.

This Feb. 26-March 1, scientists aren?t the only ones who will be making a difference. Residents of our community will have a once-in-a-generation opportunity to enroll in the American Cancer Society?s third Cancer Prevention Study which seeks to help us better understand the factors that cause or prevent cancer.

Individuals between the ages of 30 and 65 who have never been diagnosed with cancer and are willing to make a long-term commitment to the study are encouraged to sign up. Those who choose to enroll will simply fill out a comprehensive survey packet about health history, provide a small blood sample (to be collected by trained phlebotomists) and provide a waist measure. Participants will periodically be sent a follow-up questionnaire for the next 20 to 30 years.

Remember: Research being done today will help ensure future generations never have to hear those dreaded three words.

DIANE Z. WEEMS, M.D.

Chief Medical Officer

Coastal Health District/Chatham County Health
Department

Savannah

Love affair with firearms: We need honest talk

Today, America stands at a crossroads with her long-standing love affair with firearms.

The road back is an honorable tradition of a people who received the right to bear arms by a wise and forward-thinking group of Founding Fathers. Yet the present is mired with difficult problems, and the road forward is unclear.

What is the meaning, today, of the Second Amendment? Is it to give the right to procure a device whose sole purpose is to kill as many human beings in as short a time as possible, or is it to allow honest citizens the security of a firearm in a time of need?

Is it to allow to pack a clip with a hundred rounds of ammo, or is the right for our citizens to legally hunt on private and public lands? Is it both, or is it neither?

Is it time for Americans to, dare it be said, hold an honest conversation on these things, or is it still time to decry and demonize anyone with whom one might disagree?

The decision is the court of public opinion, and the race is too close to call.

ALLEN WILLIAMS

Savannah

How to escape clutches of the political parties

The Merriam-Webster Dictionary (online) defines a labor union as ?an organization of workers formed to protect the rights and interests of its members.?

Consider the focus of our major political parties. They are organizations of individuals with workers in the Congress. They espouse goals and mantras purportedly to achieve specific results. Labor unions pursue the same ends. There is no doubt both organizations seek to protect the jobs of their members.

Unions have a ?business agent? who is the chief of the group. Political parties have ?majority? or ?minority? leaders who occupy the identical responsibility ? to keep the members in line and promote their interests to the employer or legislatures. Each has benefits, such as, health insurance, pensions and tactics to accomplish their goals. There are internal disciplinary rules.

There is a way our nation could escape the self-interest of the political parties. A constitutional amendment could be adopted that congressional and state legislative districts be established by the Census Bureau which seeks each area be comprised of a similar number of individuals of male/female and age and ethnic spreads or a similar balanced composition. That would encourage the political unions to promote legislation which benefits a broad element of our society.

STANLEY HARRIS, JR.

Savannah

Politicians say anything to get elected

Money talks, and the large corporations are looking for cheap labor and the politicians are looking for money from them for their next election.

We the taxpayers are stupid not to see this. Vote every incumbent out of office; I don?t care how good he or she is. They will tell you anything to get elected.

Vote out every incumbent. They will see they are supposed to be serving voters, not big money lobbyists like Grover Norquist.

We have two members of Congress who have hired illegal aliens into their federal offices. Rep. Kyrsten Sinema, D-Ariz., hired Erika Andiola (who was brought into this country at 11 years of age). She attended college on the U.S. dollar, while we have children of American citizens who cannot afford to go.

Rep. Luis V. Gutierrez, D-Ill., hired Jose M. Quintero (the first young immigrant in Illinois to receive work authorization via Deferred Action for Childhood Arrivals) .

These are jobs that the legal American citizen would/could love to have. To me this is a slap in the face to legal American citizens.

ELIZABETH DADIN

Savannah

Source: http://savannahnow.com/opinion/2013-01-24/letters-editor-friday

south dakota state long beach state beasley trailblazers michael beasley jermaine jones hbo luck

Lenovo CFO says 'RIM and many others' are on the table as possible deals

Lenovo CFO says 'RIM and many others' are on the table as possible deals

This one is expectedly drawing a big no comment from RIM, but Bloomberg is reporting today that Lenovo has at least considered the possibility of acquiring the company or forming some other type of strategic alliance. That word comes straight from Lenovo's Chief Financial Officer, Wong Wai Ming, who said at the World Economic Forum's annual meeting in Davos that "we are looking at all opportunities -- RIM and many others," adding that, "we'll have no hesitation if the right opportunity comes along that could benefit us and shareholders." That interest has apparently extended as far as speaking to RIM and its bankers about various possible arrangements, but it's not clear when that happend or how far along the talks went. He also unsurprisingly didn't offer any indication as to when Lenovo might make a decision on the matter. As Bloomberg notes, such a deal would also a number of regulatory hurdles, including a review by the Canadian government.

Filed under: , ,

Comments

Source: Bloomberg

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/RyCdBB5GMvM/

juan pablo montoya free pancakes at ihop martina navratilova high school shooting daytona 500 national pancake day ohio school shooting